The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by major histocompatibility complex (MHC) class I molecules.Previously, we have shown that genetic or pharmacological inhibition of ERAP1 on murine and human tumor cell lines perturbs the engagement of NK cell inhibito
In the title compound, [Cu(SO4)(C12H8N2)2]·C2H6O2, the CuII ion FIBRE CLINIX COLOR BOOSTER is five-coordinated in a distorted square-pyramidal manner by four N atoms from two chelating 1,10-phenanthroline (phen) ligands and one O atom from a monodentate sulfate anion.The four N atoms comprise a square and the one O atom the apex of a squar
Astrocytes and oligodendrocytes are main players in the brain to ensure ion and neurotransmitter homeostasis, metabolic supply, and fast action potential propagation in axons.These functions are fostered by the formation of large syncytia in which mainly astrocytes and oligodendrocytes are directly coupled.Panglial networks constitute on connexin-b